Choline is widely found in free form or as a part of lecithin (phosphatidylcholine). Choline is synthesized in the body and is crucial for the normal function of all cells. It is a lipotropic B vitamin like compound that is easily absorbed from the intestine. Choline is able to cross the blood-brain barrier into the spinal fluid where it is involved in brain metabolism.

Functions of Choline:

  • Important for the integrity of cell membranes, as a methyl donor, cholinergic neurotransmission and transmembrane signaling
  • Is required for lipid transport and metabolism, exports fat from the liver and prevents fat accumulation in the liver
  • Synthesis of acetylcholine in nerves, which plays a role in brain development and function
  • Synthesis of phosphatidylcholine and sphingomyelin, structural components in cell membranes
  • Synthesis of methionine and dimethylglycine
  • A precursor of platelet-activating factor (PAF) and betain