Lemon balm, a member of the mint family, is also considered a calming herb. It was used as far back as the Middle Ages by man to reduce stress and anxiety, promote sleep, improve appetite, and ease pain and discomfort from indigestion (including gas and bloating, as well as colic). Today, lemon balm is often combined with other calming, soothing herbs, such as valerian root, chamomile, and hops, to promote relaxation.

Several studies show that lemon balm combined with other calming herbs (such as valerian root and chamomile) helps reduce anxiety and can promote calmness in animals.

Some evidence suggests that lemon balm, in combination with other herbs, may help treat indigestion (a side-effect of animal stress). Other studies show that lemon balm has a high degree of antibacterial activity.